General Information

  • ID:  hor004510
  • Uniprot ID:  Q9PRZ6
  • Protein name:  Somatostatin-26
  • Gene name:  sst1
  • Organism:  Amia calva (Bowfin)
  • Family:  Somatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Amia (genus), Amiidae (family), Amiiformes (order), Holostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SANPALAPRERKAGCKNFFWKTFTSC
  • Length:  26(1-26)
  • Propeptide:  SANPALAPRERKAGCKNFFWKTFTSC
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibit the release of somatotropin
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  15-26
  • Structure ID:  AF-Q9PRZ6-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    AF-Q9PRZ6-F1.pdbhor004510_AF2.pdbhor004510_ESM.pdb

Physical Information

Mass: 337747 Formula: C131H200N38O35S2
Absent amino acids: DHIMQVY Common amino acids: A
pI: 10.51 Basic residues: 5
Polar residues: 9 Hydrophobic residues: 9
Hydrophobicity: -55 Boman Index: -5159
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 30.38
Instability Index: 3192.69 Extinction Coefficient cystines: 5625
Absorbance 280nm: 225

Literature

  • PubMed ID:  8105513
  • Title:  Prosomatostatin-I Is Processed to somatostatin-26 and somatostatin-14 in the Pancreas of the Bowfin, Amia Calva